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KMID : 0370219960400050539
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Yakhak Hoeji
1996 Volume.40 No. 5 p.539 ~ p.544
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Synthesis of (-)-4-(p-Chlorobiphenyl)-2-hydroxytetronic Acid
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권순영/Kwon SK
Donald T. Witiak/Witiak DT
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Abstract
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4-Aryl-2-hydroxytetronic acids which can be construded as a "lipophilic vitamin C analogue", are known to have antilipidemic and antiaggregatory activities in stead of antiscorbutic activity of vitamin C. A new compound 4-(p-chlorobiphenyl)-2-hydroxytetronic acid (8), which is structurally closely connected with the most active 4-(p-chlorophenyl)-2-hydroxytetronic acid, was synthesized from alpha-(p-chlorobiphenyl)-alpha-hydroxyacetic acid (1) through 7 steps as a potentially bioactive compound.
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